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A phase 2 trial looking at two different chemotherapy treatments before surgery for pancreatic cancer

Research title: A study looking at two different neo-adjuvant chemotherapy treatments for people with pancreatic cancer who may be suitable for surgery.

Why is this trial being carried out?

Surgery is the most effective treatment for pancreatic cancer. Research has suggested that having chemotherapy before surgery may shrink the cancer. This may mean there is a better chance of removing it. The NICE guidelines recommend that chemotherapy before surgery should be looked at in clinical trials.

Chemotherapy that you have before surgery is called neo-adjuvant chemotherapy. The PRIMUS-002 trial will look at two neo-adjuvant chemotherapy treatments:

The trial will try to work out which patients are most likely to respond to chemotherapy before surgery.

If you take part in the PRIMUS-002 trial, your oncologist will decide which of the two chemotherapy treatments you will have. Your medical team will talk to you about which treatment you will have and what this treatment will involve.

This phase 2 trial is linked to the Precision Panc study. This means that you will need to join the Precision Panc study and provide blood and tissues samples in order to take part in the PRIMUS-002 trial. You may have already provided these samples during your diagnosis and treatment. Researchers will use these samples to look at the genes in your cancer. They want to see if differences in the genes affect how well the treatments work.

Who is the trial suitable for?

The PRIMUS-002 trial may be suitable for you if you:

The PRIMUS-002 trial may not be suitable for you if you:

  • have pancreatic cancer that has spread to another part of your body (advanced or metastatic pancreatic cancer)
  • have had other cancers – apart from some types of skin cancer and cervical cancer
  • have already had chemotherapy, or chemotherapy together with radiotherapy (chemoradiotherapy)
  • currently have an infection, including herpes or chickenpox
  • have a heart condition that isn’t controlled with treatment
  • have had major surgery in the month before starting the trial
  • have severe diarrhoea, and medication is not controlling this
  • have neuropathy (tingling in your fingers and toes) that affects how you can use your fingers and toes.

There may be other reasons for not being able to take part in a trial. It is important to speak to your doctor about whether this trial might be suitable for you.

Recruitment start date: March 2019

Recruitment end date: September 2022

  • Trial centres

    The PRIMUS-002 trial will be carried out in:

    • Beatson West of Scotland Cancer Centre, Glasgow
    • Western General Hospital, Edinburgh
    • Royal Free Hospital, London

    Trial lead

    Dr Derek Grose

    Contact information

    You can contact the trial centre by email on: contact@precisionpanc.org

    Or by telephone on:  0141 330 2718

  • How to join a trial

    Please speak to your consultant about whether this trial is suitable for you.

    If you have any questions about pancreatic cancer you can speak to one of our specialist nurses on freephone 0808 801 0707.

    How to find out more

    For further information about this trial please visit the UK Clinical Trials Gateway website.